Motif ID: RXRA_VDR{dimer}.p2

Z-value: 1.474


Transcription factors associated with RXRA_VDR{dimer}.p2:

Gene SymbolEntrez IDGene Name
VDR 7421 vitamin D (1,25- dihydroxyvitamin D3) receptor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
VDRchr12_-_46585032-0.117.0e-01Click!


Activity profile for motif RXRA_VDR{dimer}.p2.

activity profile for motif RXRA_VDR{dimer}.p2


Sorted Z-values histogram for motif RXRA_VDR{dimer}.p2

Sorted Z-values for motif RXRA_VDR{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXRA_VDR{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_102722275 4.240 NM_017893
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr19_-_56582997 2.271 NM_001161748
NM_030657
LIM2

lens intrinsic membrane protein 2, 19kDa

chr9_+_139245029 1.726 NM_001177316
NM_001177317
SLC34A3

solute carrier family 34 (sodium phosphate), member 3

chr21_-_46399900 1.601 NM_006657
NM_206965
FTCD

formiminotransferase cyclodeaminase

chr2_+_108271526 1.524 NM_001056
NM_176825
SULT1C2

sulfotransferase family, cytosolic, 1C, member 2

chr11_-_780103 1.477 NM_016564
CEND1
cell cycle exit and neuronal differentiation 1
chr16_-_31135895 1.473 NM_152901
PYDC1
PYD (pyrin domain) containing 1
chr16_-_4232053 1.376 NM_001098814
SRL
sarcalumenin
chr1_+_199259664 1.339


chr19_-_41090960 1.328 TYROBP
TYRO protein tyrosine kinase binding protein
chr2_+_238432925 1.315 NM_005855
RAMP1
receptor (G protein-coupled) activity modifying protein 1
chr19_-_1601246 1.284 NM_001136139
TCF3
transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
chr1_-_20122638 1.246 NM_014589
PLA2G2E
phospholipase A2, group IIE
chr17_+_2646481 1.190 NM_001100398
NM_015085
RAP1GAP2

RAP1 GTPase activating protein 2

chr2_+_74594093 1.165 TLX2
T-cell leukemia homeobox 2
chr16_+_30952350 1.132 STX4
syntaxin 4
chr11_-_64283945 1.114 PYGM
phosphorylase, glycogen, muscle
chr20_-_33658823 1.092 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chr1_-_1840564 1.083 NM_178545
TMEM52
transmembrane protein 52
chr14_+_54238581 1.029 SAMD4A
sterile alpha motif domain containing 4A
chr7_+_128365226 0.993 NM_001098629
NM_001098630
IRF5

interferon regulatory factor 5

chr16_+_30952382 0.934 NM_004604
STX4
syntaxin 4
chr18_-_6404900 0.933 NM_173464
L3MBTL4
l(3)mbt-like 4 (Drosophila)
chr17_-_31616071 0.906 NM_001001418
NM_032258
TBC1D3B
TBC1D3C
TBC1D3G
TBC1D3F
TBC1 domain family, member 3B
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3F
chr16_+_28797309 0.897 NM_004320
NM_173201
ATP2A1

ATPase, Ca++ transporting, cardiac muscle, fast twitch 1

chr22_+_48966394 0.888 TRABD
TraB domain containing
chr11_-_66945190 0.874 PPP1CA
protein phosphatase 1, catalytic subunit, alpha isozyme
chr13_+_23742846 0.865 SPATA13
spermatogenesis associated 13
chr19_-_41091023 0.850 TYROBP
TYRO protein tyrosine kinase binding protein
chr22_+_16973399 0.843 NM_001193414
NM_018943
TUBA8

tubulin, alpha 8

chr1_-_55103938 0.834 DHCR24
24-dehydrocholesterol reductase
chr11_-_124311512 0.818 NM_152722
HEPACAM
hepatic and glial cell adhesion molecule
chr22_+_16973556 0.818 TUBA8
tubulin, alpha 8
chr16_+_31027231 0.808 BCKDK
branched chain ketoacid dehydrogenase kinase
chr20_+_29931257 0.798 TTLL9
tubulin tyrosine ligase-like family, member 9
chr17_-_36469869 0.777 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr11_-_65841077 0.767 NM_020404
CD248
CD248 molecule, endosialin
chr16_+_31027115 0.760 NM_001122957
NM_005881
BCKDK

branched chain ketoacid dehydrogenase kinase

chr14_-_106352471 0.749


chr2_+_74595073 0.749 NM_016170
TLX2
T-cell leukemia homeobox 2
chr20_-_52223918 0.726 NM_000782
NM_001128915
CYP24A1

cytochrome P450, family 24, subfamily A, polypeptide 1

chr16_-_2201011 0.724 NM_182563
C16orf79
chromosome 16 open reading frame 79
chr14_+_94117483 0.715 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr4_+_1872150 0.709 NM_133334
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr7_+_39956480 0.692 NM_003718
NM_031267
CDK13

cyclin-dependent kinase 13

chr17_+_18320822 0.691 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr17_-_33552166 0.675 NM_001123391
NM_032258
TBC1D3C
TBC1D3G
TBC1D3
TBC1D3F
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3
TBC1 domain family, member 3F
chr1_-_33110668 0.666 NM_001171941
FNDC5
fibronectin type III domain containing 5
chr12_+_55896844 0.654 NM_007224
NXPH4
neurexophilin 4
chr4_+_144654526 0.653


chr19_-_41091045 0.636 NM_001173514
NM_001173515
NM_003332
NM_198125
TYROBP



TYRO protein tyrosine kinase binding protein



chr12_+_48784057 0.633 NM_005276
GPD1
glycerol-3-phosphate dehydrogenase 1 (soluble)
chr11_+_64620276 0.631 C11orf2
chromosome 11 open reading frame 2
chr17_-_36475652 0.629 NM_033184
KRTAP2-4
keratin associated protein 2-4
chr1_+_227473458 0.619 NM_004578
RAB4A
RAB4A, member RAS oncogene family
chr7_-_122126422 0.618 NM_139175
RNF133
ring finger protein 133
chr18_-_31178415 0.610 NM_006965
ZNF24
zinc finger protein 24
chr3_-_54937001 0.598 NM_020678
LRTM1
leucine-rich repeats and transmembrane domains 1
chr17_+_22823151 0.594 NM_014238
KSR1
kinase suppressor of ras 1
chr3_+_48239865 0.594 NM_004345
CAMP
cathelicidin antimicrobial peptide
chr17_+_77528699 0.591 NM_024083
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr11_+_64620287 0.570 C11orf2
chromosome 11 open reading frame 2
chr15_+_89229275 0.562 NM_001143783
NM_001143784
FES

feline sarcoma oncogene

chr10_-_33663777 0.540 NM_001024628
NM_001024629
NM_003873
NRP1


neuropilin 1


chr1_-_201583989 0.536 FMOD
fibromodulin
chrX_-_109570113 0.533 NM_001171689
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr10_+_11087259 0.531 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr11_+_64620183 0.516 NM_013265
C11orf2
chromosome 11 open reading frame 2
chrX_+_46825179 0.513 RGN
regucalcin (senescence marker protein-30)
chr10_-_33663984 0.507 NRP1
neuropilin 1
chr1_-_199348316 0.502 NM_000069
CACNA1S
calcium channel, voltage-dependent, L type, alpha 1S subunit
chr7_+_97679501 0.501 NM_177455
BHLHA15
basic helix-loop-helix family, member a15
chr18_-_31178379 0.500 ZNF24
zinc finger protein 24
chr16_+_55950195 0.499 NM_002990
CCL22
chemokine (C-C motif) ligand 22
chr16_+_31027249 0.489 BCKDK
branched chain ketoacid dehydrogenase kinase
chr12_+_54700955 0.487 NM_022465
IKZF4
IKAROS family zinc finger 4 (Eos)
chr9_+_130684601 0.486 NM_001127244
LRRC8A
leucine rich repeat containing 8 family, member A
chr9_+_130838720 0.484 FAM73B
family with sequence similarity 73, member B
chr8_+_22493928 0.482 NM_176871
NM_198042
PDLIM2

PDZ and LIM domain 2 (mystique)

chr11_+_60626505 0.481 NM_014207
CD5
CD5 molecule
chr17_-_20311411 0.466 NM_001042685
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr2_-_27457088 0.462 NM_144631
ZNF513
zinc finger protein 513
chr17_-_8006979 0.460 NM_014232
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr1_-_39929654 0.459 NM_016257
HPCAL4
hippocalcin like 4
chr8_+_76482661 0.456 HNF4G
hepatocyte nuclear factor 4, gamma
chr16_+_18986417 0.454 NM_016138
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr2_+_128175413 0.451 SFT2D3
SFT2 domain containing 3
chr17_+_77528782 0.438 ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr11_+_2378559 0.437 TSSC4
tumor suppressing subtransferable candidate 4
chr16_-_65742323 0.436 NM_033309
B3GNT9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr11_-_780065 0.433 CEND1
cell cycle exit and neuronal differentiation 1
chr16_+_14634324 0.427 BFAR
bifunctional apoptosis regulator
chr6_+_30960305 0.423 NM_013993
DDR1
discoidin domain receptor tyrosine kinase 1
chr1_+_173303616 0.422 NM_022093
TNN
tenascin N
chr3_-_71196696 0.418 FOXP1
forkhead box P1
chr17_-_74289901 0.413 NM_004762
NM_017456
CYTH1

cytohesin 1

chr19_+_13111072 0.412 NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr7_+_39956396 0.406


chr11_-_77468912 0.405 NM_004549
NDUFC2
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
chr5_-_178984192 0.398 HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr4_+_6726555 0.397 LOC93622
hypothetical LOC93622
chr21_-_45165249 0.395 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr9_+_138367329 0.395 NM_001145639
GPSM1
G-protein signaling modulator 1
chr1_+_156716290 0.392 NM_001004472
OR10R2
olfactory receptor, family 10, subfamily R, member 2
chr20_+_41628150 0.392 NM_016276
SGK2
serum/glucocorticoid regulated kinase 2
chr7_-_44547382 0.389 NM_001101648
NM_013389
NPC1L1

NPC1 (Niemann-Pick disease, type C1, gene)-like 1

chr12_+_119900677 0.388 HNF1A
HNF1 homeobox A
chr12_+_27740694 0.385 NM_001029874
REP15
RAB15 effector protein
chr4_+_2764510 0.384 NM_001122681
SH3BP2
SH3-domain binding protein 2
chr12_+_77963563 0.379 NM_001135806
SYT1
synaptotagmin I
chr17_+_4434024 0.375 NM_198501
SMTNL2
smoothelin-like 2
chr19_-_52679222 0.375 KPTN
kaptin (actin binding protein)
chr13_-_50315832 0.367 NM_198989
DLEU7
deleted in lymphocytic leukemia, 7
chr1_+_224803123 0.366 NM_001003665
C1orf95
chromosome 1 open reading frame 95
chrX_-_39921525 0.365 NM_001123383
NM_001123384
BCOR

BCL6 corepressor

chr16_+_31027255 0.364 BCKDK
branched chain ketoacid dehydrogenase kinase
chr14_+_94117511 0.363 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr1_+_44171578 0.359 NM_001136215
NM_057090
NM_057091
ARTN


artemin


chr21_+_44169706 0.357 NM_001037553
AGPAT3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr20_+_3749164 0.354 NM_018347
C20orf29
chromosome 20 open reading frame 29
chr17_-_31528027 0.353 NM_001001417
TBC1D3B
TBC1D3C
TBC1D3G
TBC1D3F
TBC1 domain family, member 3B
TBC1 domain family, member 3C
TBC1 domain family, member 3G
TBC1 domain family, member 3F
chr1_+_154816142 0.350 NM_001105669
TTC24
tetratricopeptide repeat domain 24
chr19_-_47451119 0.348 NM_006494
ERF
Ets2 repressor factor
chr16_+_28211123 0.346 NM_001024401
SBK1
SH3-binding domain kinase 1
chr19_+_47509274 0.345 NM_173633
TMEM145
transmembrane protein 145
chr9_-_135593265 0.345 NM_001134707
SARDH
sarcosine dehydrogenase
chr11_+_1170045 0.341 MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
chr7_+_39956633 0.341 CDK13
cyclin-dependent kinase 13
chr15_-_87565813 0.341 NM_000326
RLBP1
retinaldehyde binding protein 1
chr6_-_42124587 0.336 NM_001136017
NM_001136126
CCND3

cyclin D3

chr19_+_11936868 0.336 NM_001012753
ZNF763
zinc finger protein 763
chr21_-_45165204 0.335 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr17_-_36456949 0.333 NM_001123387
KRTAP2-1
keratin associated protein 2-1
chr12_+_56299959 0.331 NM_133489
SLC26A10
solute carrier family 26, member 10
chr3_-_153470022 0.331 LOC401093
hypothetical LOC401093
chr1_-_16217871 0.329 NM_014424
HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr7_+_128365482 0.328 NM_032643
IRF5
interferon regulatory factor 5
chr3_-_13032130 0.328


chr17_-_61655915 0.327 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr16_+_18986459 0.325 COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr10_-_22332646 0.319 NM_022365
DNAJC1
DnaJ (Hsp40) homolog, subfamily C, member 1
chr5_-_92982927 0.319


chr21_+_44699796 0.318 NM_030891
LRRC3
leucine rich repeat containing 3
chr10_+_115929008 0.309 NM_198795
TDRD1
tudor domain containing 1
chr1_+_224803226 0.309 C1orf95
chromosome 1 open reading frame 95
chr19_+_10515570 0.306 ATG4D
ATG4 autophagy related 4 homolog D (S. cerevisiae)
chr16_+_14634168 0.306 NM_016561
BFAR
bifunctional apoptosis regulator
chr1_+_46910086 0.305 NM_001145474
C1orf223
chromosome 1 open reading frame 223
chr16_+_27320983 0.303 NM_181078
NM_181079
IL21R

interleukin 21 receptor

chr14_+_102921528 0.299 MARK3
MAP/microtubule affinity-regulating kinase 3
chr14_+_49429474 0.296 NM_001663
ARF6
ADP-ribosylation factor 6
chr2_+_111206620 0.296 NM_001142807
ACOXL
acyl-CoA oxidase-like
chr14_-_93926679 0.296 NM_001002235
NM_001002236
NM_001127700
NM_001127701
NM_001127702
NM_001127703
NM_001127704
NM_001127705
NM_001127706
NM_001127707
SERPINA1









serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1









chr16_+_620932 0.295 NM_053284
WFIKKN1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr7_+_142788480 0.293 NM_001010972
NM_003461
ZYX

zyxin

chr12_+_121001059 0.291 NM_014938
MLXIP
MLX interacting protein
chr7_+_142788579 0.289 ZYX
zyxin
chr19_-_12028126 0.285 NM_001080404
ZNF878
zinc finger protein 878
chr6_-_91063301 0.282 NM_001170794
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr22_-_41158306 0.282 NM_145912
NFAM1
NFAT activating protein with ITAM motif 1
chr17_-_70367479 0.282 NM_000835
GRIN2C
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
chr14_+_23508922 0.279 NM_001193636
NM_001193637
NM_001193635
DHRS4L2


DHRS4L1
dehydrogenase/reductase (SDR family) member 4 like 2


dehydrogenase/reductase (SDR family) member 4 like 1
chr21_+_39099717 0.276 NM_005239
ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr2_-_230494862 0.274 NM_004238
TRIP12
thyroid hormone receptor interactor 12
chr12_-_53044495 0.273 NM_020370
GPR84
G protein-coupled receptor 84
chr16_-_88295595 0.271 NM_152339
SPATA2L
spermatogenesis associated 2-like
chr19_-_48700824 0.270 NM_198850
PHLDB3
pleckstrin homology-like domain, family B, member 3
chr7_+_99263571 0.268 NM_022820
NM_057095
NM_057096
CYP3A43


cytochrome P450, family 3, subfamily A, polypeptide 43


chr4_+_2764609 0.268 SH3BP2
SH3-domain binding protein 2
chr20_-_42457717 0.268


chr19_-_52679287 0.265 NM_007059
KPTN
kaptin (actin binding protein)
chr4_+_6726699 0.265 LOC93622
hypothetical LOC93622
chr19_-_12305435 0.264 NM_145276
ZNF563
zinc finger protein 563
chr1_-_27604656 0.264 WASF2
WAS protein family, member 2
chr18_-_72973698 0.263 MBP
myelin basic protein
chr6_+_31538934 0.262 NM_006674
HCP5
HLA complex P5
chr11_+_63754328 0.259 NM_005528
DNAJC4
DnaJ (Hsp40) homolog, subfamily C, member 4
chr20_+_61963009 0.257 NM_080622
ABHD16B
abhydrolase domain containing 16B
chr8_-_139995417 0.257 NM_152888
COL22A1
collagen, type XXII, alpha 1
chr1_-_203592538 0.245 NM_018203
KLHDC8A
kelch domain containing 8A
chr18_+_19706979 0.244 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr13_+_23723831 0.242 SPATA13
spermatogenesis associated 13
chr16_+_18986721 0.242 NM_001190983
COQ7
coenzyme Q7 homolog, ubiquinone (yeast)
chr8_-_37576515 0.242 LOC157860
hypothetical protein LOC157860
chr1_-_181826292 0.241 NM_000433
NM_001190789
NM_001190794
NCF2


neutrophil cytosolic factor 2


chr21_+_39099624 0.239 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr4_-_35922288 0.237 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr18_+_46340400 0.235 NM_002747
MAPK4
mitogen-activated protein kinase 4
chr16_-_28210867 0.233


chr13_-_52211836 0.227 LECT1
leukocyte cell derived chemotaxin 1
chr17_+_23875085 0.226 NM_003593
FOXN1
forkhead box N1
chr10_+_11087345 0.225 CELF2
CUGBP, Elav-like family member 2
chr6_-_166960690 0.224 NM_021135
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr2_-_200028977 0.223 SATB2
SATB homeobox 2
chr19_-_12456625 0.223 NM_152601
ZNF709
zinc finger protein 709
chr3_+_185515108 0.218 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr2_+_11600287 0.217 NM_033090
GREB1
growth regulation by estrogen in breast cancer 1
chr6_-_91063181 0.217 NM_021813
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr5_-_63293715 0.217 HTR1A
5-hydroxytryptamine (serotonin) receptor 1A
chr15_+_57691272 0.217 NM_004751
GCNT3
glucosaminyl (N-acetyl) transferase 3, mucin type

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment   p-value GO term description
8.51 1.05e-03 GO:0003823 antigen binding
2.47 3.05e-02 GO:0008047 enzyme activator activity